SANTA FE, N.M. — Actor Gene Hackman died of heart disease a full week after his wife died from hantavirus in their New Mexico hillside home, likely unaware that she was dead because he was in the advanced stages of Alzheimer’s disease, authorities revealed Friday.

Both deaths were ruled to be from natural causes, chief medical examiner Dr. Heather Jarrell said alongside state fire and health officials at a news conference.

“Mr. Hackman showed evidence of advanced Alzheimer’s disease,” Jarrell said. “He was in a very poor state of health. He had significant heart disease, and I think ultimately that’s what resulted in his death.”

Authorities didn’t suspect foul play after the bodies of Hackman, 95, and Betsy Arakawa, 65, were discovered Feb 26. Immediate tests for carbon monoxide poisoning were negative.

Investigators found that the last known communication and activity from Arakawa was Feb. 11 when she visited a pharmacy, pet store and grocery before returning to their gated neighborhood that afternoon, Santa Fe County Sheriff Adan Mendoza said Friday.

Hackman’s pacemaker last showed signs of activity a week later and that he had an abnormal heart rhythm on Feb. 18., the day he likely died, Jarrell said.

Although there was no reliable way to determine the date and time when both died, all signs point to their deaths coming a week apart, Jarrell said.

“It’s quite possible he was not aware she was deceased,” Jarrell said.

Dr. Michael Baden, a former New York City medical examiner, said he believes Hackman was severely impaired due to Alzheimer’s disease and unable to deal with his wife’s death in the last week of his life.

“You are talking about very severe Alzheimer’s disease that normal people would be in a nursing home or have a nurse, but she was taking care of him until she passed away,” Baden said.

Their bodies were found a little over a week later. Hackman was found in the home’s entryway. His death was tied to heart disease with Alzheimer’s disease contributing.

Arakawa was found in a bathroom. Authorities linked her death to hantavirus pulmonary syndrome, a rare but potentially fatal disease spread by infected rodent droppings. Thyroid medication pills prescribed to Arakawa were found nearby and weren’t listed as contributing to her death, Jarrell said.

Hantavirus typically is reported in spring and summer, often due to exposures that occur when people are near mouse droppings in homes, sheds or poorly ventilated areas. This is the first confirmed case of hantavirus in New Mexico this year.

While hantavirus is found throughout the world, most cases in the U.S. have been found in western states. The virus can cause a severe and sometimes deadly lung infection. Symptoms can include coughing, shortness of breath and tightness in the chest.

Jarrell said it was not known how quickly Arakawa died.

Investigators earlier retrieved personal items from the couple’s home, including a monthly planner and two cellphones.

One of the couple’s three dogs also was found dead in a crate in a bathroom closet near Arakawa, while two other dogs survived. Authorities initially misidentified the breed.